GNU Collaborative International Dictionary of English

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Found one definition

1.       
   Guinea pig [Prob. a mistake for Guiana pig.]
   1. (Zool.) A small Brazilian rodent (Cavia porcellus or Cavia cobaya), about seven inches in length and usually of a white color, with spots of orange and black.  Called also cavy.  It is the domesticated form of the wild cavy, often kept as a pet and used commonly as an experimental animal in laboratory research.
   
   [Webster 1913 Suppl. +PJC]
   
   
   2. Hence, [figuratively]: Any animal or person used in an experiment; -- also applied to people who are unwillingly or unknowingly subjected by authorities to policies or procedures which might cause bodily or mental harm.
   
   [PJC]
   
   
   3. A contemptuous sobriquet. [Obs.] Smollett
   
   [Webster 1913 Suppl. +PJC]