GNU Collaborative International Dictionary of English
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Found one definition
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defuse (dḗ‑fūzˈ), v. t. [Cf. Diffuse.]
1. To disorder; to make shapeless. [Obs.] Shak.
[1913 Webster]
2. To remove the fuse from; to deactivate (a bomb or other explosive device) or make it ineffective.
Syn. -- deactivate.
[WordNet 1.5 +PJC]
3. To make less dangerous; as, “to defuse a tense confrontation between demonstrators and police”.
[PJC]