GNU Collaborative International Dictionary of English

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Found one definition

1.       
   ligase n. (Biochem.) An enzyme which catalyzes creation of a covalent bond between two substrates, resulting in a larger product which is a combination of the two starting materials;  especially, DNA ligase, an enzyme which creates a phosphate bond between 5´ and 3´ ends of a DNA chain, resulting in a longer chain of DNA.  DNA ligase is important in normal biosynthesis of DNA in the replication cycle of cells.
   
   [PJC]