GNU Collaborative International Dictionary of English

Found one definition

1.       
   Vicissitude , n. [L. vicissitudo, fr. vicis change, turn: cf. F. vicissitude. See Vicarious.]
   1913 Webster
   Regular change or succession from one thing to another; alternation; mutual succession; interchange.
   1913 Webster
   God made two great lights . . . 
   To illuminate the earth and rule the day
   In their vicissitude, and rule the night.
   Milton.
   
   1913 Webster
   Irregular change; revolution; mutation.
   1913 Webster
    (pl.) Changing conditions of fortune in one's life; life's ups and downs.
   PJC
   This man had, after many vicissitudes of fortune, sunk at last into abject and hopeless poverty.
   Macaulay.
   
   1913 Webster